Endocrine Abstracts

Involvement of BMP-3b (also called GDF-10) in osteogenesis, embryogenesis and adipogenesis has been reported to date. However, the functional receptors and intracellular signaling of BMP-3b have yet to be determined. In the present study, we studied the cellular mechanism of BMP-3b in osteoblast differentiation using mouse myoblastic C2C12 cells, which show osteoblasitc differentiation in response to osteogenetic BMP ligands. BMP-3b stimulated activin/TGF-β-responsive pro...